diff --git a/src/video_core/pica/pica_core.cpp b/src/video_core/pica/pica_core.cpp
index 91e06252d..f09210a29 100644
--- a/src/video_core/pica/pica_core.cpp
+++ b/src/video_core/pica/pica_core.cpp
@@ -58,6 +58,7 @@ void PicaCore::InitializeRegs() {
     // Values initialized by GSP
     regs.internal.irq_autostop = 1;
     regs.internal.irq_mask = 0xFFFFFFF0;
+    regs.internal.irq_compare = 0x12345678;
 
     auto& framebuffer_top = regs.framebuffer_config[0];
     auto& framebuffer_sub = regs.framebuffer_config[1];
@@ -134,6 +135,11 @@ void PicaCore::ProcessCmdList(PAddr list, u32 size, bool ignore_list) {
     }
 }
 
+static bool any_byte_match(u32 a, u32 b) {
+    return ((a & 0xFF) == (b & 0xFF)) || (((a >> 8) & 0xFF) == ((b >> 8) & 0xFF)) ||
+           (((a >> 16) & 0xFF) == ((b >> 16) & 0xFF)) || (((a >> 24) & 0xFF) == ((b >> 24) & 0xFF));
+}
+
 void PicaCore::WriteInternalReg(u32 id, u32 value, u32 mask, bool& stop_requested) {
     if (id >= RegsInternal::NUM_REGS) {
         LOG_ERROR(
@@ -168,7 +174,9 @@ void PicaCore::WriteInternalReg(u32 id, u32 value, u32 mask, bool& stop_requeste
     switch (id) {
     // Trigger IRQ
     case PICA_REG_INDEX(irq_request):
-        if (regs.internal.reg_array[id] != 0) [[likely]] {
+        // TODO(PabloMK7): This logic is not fully accurate, but close enough:
+        // https://problemkaputt.de/gbatek-3ds-gpu-internal-registers-finalize-interrupt-registers.htm
+        if (any_byte_match(regs.internal.reg_array[id], regs.internal.irq_compare)) [[likely]] {
             signal_interrupt(Service::GSP::InterruptId::P3D,
                              delay_generator.CalculateAndResetDelay());
             if (regs.internal.irq_autostop) [[likely]] {