diff --git a/src/video_core/CMakeLists.txt b/src/video_core/CMakeLists.txt
index 25eb7846b4..be53b71393 100644
--- a/src/video_core/CMakeLists.txt
+++ b/src/video_core/CMakeLists.txt
@@ -323,7 +323,10 @@ if (ENABLE_OPENGL)
 endif()
 
 target_link_libraries(video_core PUBLIC common core)
-target_link_libraries(video_core PUBLIC glad shader_recompiler stb bc_decoder gpu_logging)
+target_link_libraries(video_core PUBLIC shader_recompiler stb bc_decoder gpu_logging)
+if (ENABLE_OPENGL)
+    target_link_libraries(video_core PUBLIC glad)
+endif()
 
 if (YUZU_USE_EXTERNAL_FFMPEG)
     add_dependencies(video_core ffmpeg-build)
diff --git a/src/yuzu/CMakeLists.txt b/src/yuzu/CMakeLists.txt
index 3adce1dd8b..ff0312660b 100644
--- a/src/yuzu/CMakeLists.txt
+++ b/src/yuzu/CMakeLists.txt
@@ -411,8 +411,11 @@ endif()
 
 target_link_libraries(yuzu PRIVATE nlohmann_json::nlohmann_json)
 target_link_libraries(yuzu PRIVATE common core input_common frontend_common network video_core qt_common)
-target_link_libraries(yuzu PRIVATE Boost::headers glad Qt6::Widgets Qt6::Charts Qt6::Concurrent)
+target_link_libraries(yuzu PRIVATE Boost::headers Qt6::Widgets Qt6::Charts Qt6::Concurrent)
 target_link_libraries(yuzu PRIVATE ${PLATFORM_LIBRARIES} Threads::Threads)
+if (ENABLE_OPENGL)
+    target_link_libraries(yuzu PRIVATE glad)
+endif()
 
 if (UNIX AND NOT APPLE)
     target_link_libraries(yuzu PRIVATE Qt6::DBus)
diff --git a/src/yuzu/bootmanager.cpp b/src/yuzu/bootmanager.cpp
index 0c0ce6e90c..f7adb1b693 100644
--- a/src/yuzu/bootmanager.cpp
+++ b/src/yuzu/bootmanager.cpp
@@ -8,7 +8,10 @@
 #include <string>
 #include <tuple>
 #include <type_traits>
+
+#ifdef HAS_OPENGL
 #include <glad/glad.h>
+#endif
 
 #include <QtCore/qglobal.h>
 #include "common/settings_enums.h"
@@ -1039,6 +1042,7 @@ void GRenderWindow::InitializeNull() {
 }
 
 bool GRenderWindow::LoadOpenGL() {
+#ifdef HAS_OPENGL
     auto context = CreateSharedContext();
     auto scope = context->Acquire();
     if (!gladLoadGL()) {
@@ -1069,6 +1073,12 @@ bool GRenderWindow::LoadOpenGL() {
         // Non fatal
     }
     return true;
+#else
+    QMessageBox::warning(
+        this, tr("Error while initializing OpenGL!"),
+        tr("This build doesn't have OpenGL support."));
+    return false;
+#endif
 }
 
 QStringList GRenderWindow::GetUnsupportedGLExtensions() const {
diff --git a/src/yuzu_cmd/CMakeLists.txt b/src/yuzu_cmd/CMakeLists.txt
index 8f92525ad6..ba2e6c5209 100644
--- a/src/yuzu_cmd/CMakeLists.txt
+++ b/src/yuzu_cmd/CMakeLists.txt
@@ -15,11 +15,18 @@ function(create_resource file output filename)
     file(WRITE "${PROJECT_BINARY_DIR}/dist/${output}" "const unsigned char ${filename}[] = {${filedata}};\nconst unsigned ${filename}_size = sizeof(${filename});\n")
 endfunction()
 
+if (ENABLE_OPENGL)
+    list(OPENGL_SOURCES APPEND
+        emu_window/emu_window_sdl2_gl.cpp
+        emu_window/emu_window_sdl2_gl.h
+    )
+else()
+    set(OPENGL_SOURCES "")
+endif()
+
 add_executable(yuzu-cmd
     emu_window/emu_window_sdl2.cpp
     emu_window/emu_window_sdl2.h
-    emu_window/emu_window_sdl2_gl.cpp
-    emu_window/emu_window_sdl2_gl.h
     emu_window/emu_window_sdl2_null.cpp
     emu_window/emu_window_sdl2_null.h
     emu_window/emu_window_sdl2_vk.cpp
@@ -28,10 +35,13 @@ add_executable(yuzu-cmd
     sdl_config.h
     yuzu.cpp
     yuzu.rc
+    ${OPENGL_SOURCES}
 )
 
 target_link_libraries(yuzu-cmd PRIVATE common core input_common frontend_common video_core)
-target_link_libraries(yuzu-cmd PRIVATE glad)
+if (ENABLE_OPENGL)
+    target_link_libraries(yuzu-cmd PRIVATE glad)
+endif()
 if (MSVC)
     target_link_libraries(yuzu-cmd PRIVATE getopt)
 endif()
diff --git a/src/yuzu_cmd/yuzu.cpp b/src/yuzu_cmd/yuzu.cpp
index 8e518d816c..54cc832bf2 100644
--- a/src/yuzu_cmd/yuzu.cpp
+++ b/src/yuzu_cmd/yuzu.cpp
@@ -31,7 +31,9 @@
 #include "sdl_config.h"
 #include "video_core/renderer_base.h"
 #include "yuzu_cmd/emu_window/emu_window_sdl2.h"
+#ifdef HAS_OPENGL
 #include "yuzu_cmd/emu_window/emu_window_sdl2_gl.h"
+#endif
 #include "yuzu_cmd/emu_window/emu_window_sdl2_null.h"
 #include "yuzu_cmd/emu_window/emu_window_sdl2_vk.h"
 
@@ -349,17 +351,22 @@ int main(int argc, char** argv) {
 
     std::unique_ptr<EmuWindow_SDL2> emu_window;
     switch (Settings::values.renderer_backend.GetValue()) {
+#ifdef HAS_OPENGL
     case Settings::RendererBackend::OpenGL_GLSL:
     case Settings::RendererBackend::OpenGL_GLASM:
     case Settings::RendererBackend::OpenGL_SPIRV:
         emu_window = std::make_unique<EmuWindow_SDL2_GL>(&input_subsystem, system, fullscreen);
         break;
+#endif
     case Settings::RendererBackend::Vulkan:
         emu_window = std::make_unique<EmuWindow_SDL2_VK>(&input_subsystem, system, fullscreen);
         break;
     case Settings::RendererBackend::Null:
         emu_window = std::make_unique<EmuWindow_SDL2_Null>(&input_subsystem, system, fullscreen);
         break;
+    default:
+        LOG_CRITICAL(Frontend, "Invalid renderer backend");
+        return -1;
     }
 
 #ifdef _WIN32