diff --git a/src/dynarmic/src/dynarmic/common/spin_lock_x64.cpp b/src/dynarmic/src/dynarmic/common/spin_lock_x64.cpp
index 1a80ae638a..f1898a92ef 100644
--- a/src/dynarmic/src/dynarmic/common/spin_lock_x64.cpp
+++ b/src/dynarmic/src/dynarmic/common/spin_lock_x64.cpp
@@ -90,6 +90,8 @@ std::once_flag flag;
 std::optional<SpinLockImpl> impl;
 
 void SpinLockImpl::Initialize() noexcept {
+    // Needed for W^X systems (i.e SElinux, OpenBSD)
+    code.setProtectMode(Xbyak::CodeArray::ProtectMode::PROTECT_RW);
     Xbyak::Reg64 const ABI_PARAM1 = Backend::X64::HostLocToReg64(Backend::X64::ABI_PARAM1);
     code.align();
     lock = code.getCurr<void (*)(volatile int*)>();
@@ -99,6 +101,7 @@ void SpinLockImpl::Initialize() noexcept {
     unlock = code.getCurr<void (*)(volatile int*)>();
     EmitSpinLockUnlock(code, ABI_PARAM1, code.eax);
     code.ret();
+    code.setProtectMode(Xbyak::CodeArray::ProtectMode::PROTECT_RE);
 }
 
 void SpinLockImpl::GlobalInitialize() noexcept {
diff --git a/src/video_core/macro.cpp b/src/video_core/macro.cpp
index dbf011860e..76a054665c 100644
--- a/src/video_core/macro.cpp
+++ b/src/video_core/macro.cpp
@@ -1117,6 +1117,8 @@ void MacroJITx64Impl::Optimizer_ScanFlags() {
 }
 
 void MacroJITx64Impl::Compile() {
+    // Matching PROTECT_RE needed for W^X systems
+    setProtectMode(Xbyak::CodeArray::ProtectMode::PROTECT_RW);
     labels.fill(Xbyak::Label());
 
     Common::X64::ABI_PushRegistersAndAdjustStack(*this, Common::X64::ABI_ALL_CALLEE_SAVED, 8);
@@ -1164,6 +1166,7 @@ void MacroJITx64Impl::Compile() {
     Common::X64::ABI_PopRegistersAndAdjustStack(*this, Common::X64::ABI_ALL_CALLEE_SAVED, 8);
     ret();
     ready();
+    setProtectMode(Xbyak::CodeArray::ProtectMode::PROTECT_RE);
     program = getCode<ProgramType>();
 }